Gypsum is an evaporite mineral most commonly found in layered sedimentary deposits in association with halite, anhydrite, sulfur, calcite, and dolomite. Gypsum (CaSO4.2H2O) is very similar to Anhydrite (CaSO4). The chemical difference is that gypsum contains two waters and anhydrite is without water. Gypsum is the most common sulfate mineral. gypsum wallboard and plaster. Gypsum wallboard and plaster: Wallboard and construction plaster are the primary industrial uses of gypsum. Uses of Gypsum. Gypsum uses include: manufacture of wallboard, cement, plaster of Paris, soil conditioning, a hardening retarder in portland cement. Varieties of gypsum known as "satin spar" and "alabaster" are used for a variety of ornamental purposes; however, their low hardness limits their durability.